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KMID : 0881720100250010006
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Journal of Food Hygiene and Safety
2010 Volume.25 No. 1 p.6 ~ p.9
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Evaluation of Antibacterial Effects of a Combination of Coptidis Rhizoma, Lonicerae Flos, Paeonia Japonica Extracts, and Dioctahedral Smectite Against Salmonella Typhimurium in Murine Salmonellosis
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Jung Won-Chul
Lee Yeon-Ok
Cha Chun-Nam
Lee Yeo-Eun
Kim Gon-Sup
Lee Hu-Jang
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Abstract
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The present study was undertaken to estimate the antibacterial effect of a combination of C. rhizoma, L. Flos, and P. japonica (1:1:1) extracts (CLP1000) and a combination of the herbal extract mixture and dioctahedral smectite (CLPS1000) against murine salmonellosis. At the concentration of CLP1000 and CLPS1000 0.5 mg/ml, the antibacterial effect was not showed on Salmonella typhimurium (S. typhimurium). On the other hand, the antibacterial effect against S. typhimurium was observed at the concentration of CLP1000 and CLPS1000 1.0 mg/ml. Oral administration of Smectite, CLP1000, and CLPS1000 at the dose of 10 mg/ml showed a therapeutic effect for S. typhimurium infected BALB/c mice. The mortality of Smectite, CLP1000 and CLPS1000-treated mice was 90%, 90%, and 70% at 12 days, respectively, while that of untreated mice was 100% at 9 days after a lethal dose of S. typhimurium infection. The results of our study strongly indicate that CLPS1000 has potential as an effective of salmonellosis.
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KEYWORD
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Coptidis rhizoma, Lonicerae Flos, Paeonia japonica, dioctahedral smectite, Salmonella typhimurium
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